Hello,

I am investigating several genes using the Branch-site REL program on datamonkey. If my gene is, e.g., BRCA1, should I construct a phylogeny based on BRCA1 or should I use a true phylogeny (i.e., one which accurately reflects the relatedness of the species)?

Thanks.

Hi there,

It depends on whether or not the gene tree mirrors the species tree. I don't know whether or not this is the case for BRCA1. Generally speaking, you are better off using the accurately reconstructed gene tree.

Sergei


anlagers2 wrote on Jul 4^th, 2012 at 4:31am:

Hello, I am investigating several genes using the Branch-site REL program on datamonkey. If my gene is, e.g., BRCA1, should I construct a phylogeny based on BRCA1 or should I use a true phylogeny (i.e., one which accurately reflects the relatedness of the species)? Thanks.