Email Me
sdfrost_at_ucsd.edu
C.V.
  

Welcome to simonfrost.com!

I work at the Antiviral Research Center, part of the University of California, San Diego.

My research interests include:

  • Viral dynamics and evolution
  • Biostatistics, especially spline smoothing and Bayesian methods
  • Sequence analysis and phylogenetic methods
  • Individual based modelling

Software projects

I'm involved (in varying degrees) in several software projects, mainly using the excellent Python language. I'll link these in soon.

Publications

  1. Frost, S.D.W. & McLean, A.R. (1994a) Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection. AIDS 8, 323-332.
  2. Frost, S.D.W. & McLean, A.R. (1994b) Germinal centre destruction as a major pathway of HIV pathogenesis. J. AIDS 7, 236-244.
  3. McLean, A.R. & Frost, S.D.W. (1995) Zidovudine & HIV: mathematical models of within-host population dynamics. Rev. Med. Virol. 5, 141-148.
  4. Frost, S.D.W. (1995) The Within-Host Dynamics of HIV-1 Infection. D.Phil. thesis, University of Oxford.
  5. Frost, S.D.W. & Michie, C.A. (1996) Lymphocyte dynamics, apoptosis and HIV infection. Trends Microbiol. 4, 77-82.6
  6. Krebs, J.R., Anderson, R.M., Clutton-Brock, T., Morrison, W.I., Young, D., Donnelly, C.A., Frost, S.D.W. & Woodroffe, R. (1997) Bovine Tuberculosis in Cattle and Badgers. Report to the Ministry of Agriculture, Fisheries and Food. MAFF Publications, London, UK.
  7. Krebs, J.R., Anderson, R.M., Clutton-Brock, T., Donnelly, C.A., Frost, S., Morrison, W.I., Woodroffe, R. & Young, D. (1998) Badgers and bovine TB: conflicts between conservation and health. Science 279, 817-818, 1998.
  8. Frost, S.D.W. (1999) The Immune System as an Inducible Defense. Chapter 8 in: Harvell, C.D. & Tollrian, R., eds. The Ecology and Evolution of Inducible Defenses. Princeton University Press.
  9. Woodroffe, R, Frost, S.D.W. & Clifton-Hadley, R.C. (1999) Attempts to control tuberculosis in cattle by removing infected badgers: constraints imposed by live test sensitivity. J. Appl. Ecol. 36, 494-501.
  10. Günthard, H.F., Frost, S.D.W., Leigh Brown, A.J., Ignacio, C.C., Kee, K., Perelson, A.S., Spina, C.A., Havlir, D.V., Hezareh, M., Looney, D.J., Richman, D.D. & Wong, J.K. (1999) Evolution of envelope sequences of HIV-1 in cellular reservoirs in the setting of potent antiviral therapy. J. Virol. 11, 9404-9412.
  11. Smith, D.B., Basaras, M., Frost, S.D.W., Haydon, D., Cuceanau, N., Prescott, L., Kamenka, C., Millband, D., Sathar, M.A. & Simmonds, P. (2000) Phylogenetic analysis of GBV-C/hepatitis G virus. J. Gen. Virol. 81, 769-780.
  12. Frost, S.D.W., Nijhuis, M., Schuurman, R., Boucher, C.A.B. & Leigh Brown, A.J. (2000) Evolution of lamivudine resistance in human immunodeficiency virus type-1 infected individuals: the relative roles of drift and selection. J. Virol. 74, 6262-6268.
  13. Frost, S.D.W. (2001) Bayesian modeling of HIV evolution and dynamics. AIDS Cyber J 4(2).
  14. Günthard, H.F., Havlir, D.V. Fiscus, S., Zhang, Z.-Q., Eron, J., Mellors, J., Gulick, R., Frost, S.D.W., Leigh Brown, A.J., Schleif, W., Valentine, F., Jonas, J., Meibohm, A., Ignacio, C.C., Isaacs, R., Gamagami, R., Emini, E., Haase, A., Richman, D.D. & Wong, J.K. (2001) Residual Human Immunodeficiency Virus-1 RNA and DNA in Lymph Node and HIV RNA in Genital Secretions and in Cerebro Spinal Fluid after Two Years of Suppression of Viremia in the Merck 035 cohort. J. Inf. Dis. 183, 1318-1327.
  15. Frost, S.D.W., Günthard, H.F., Wong, J.K., Havlir, D., Richman, D.D. & Leigh Brown, A.J. (2001) Evidence for positive selection driving the evolution of HIV env under potent antiviral therapy. Virology 284:250-258.
  16. Ruiz, L., Carcelain, G., Martinez-Picado, J., Frost, S., Marfil, S., Paredes, R., Romeu, J., Ferrer, E., Morales-Lopetegi, K., Zayat, M.K., Autran, B. & Clotet, B. (2001) HIV-specific CD8+ T cells and HIV dynamics after three structured treatment interruptions in chronic HIV infection. AIDS 15:F19-F27.
  17. Frost, S.D.W., Dumaurier, M.-J., Wain-Hobson, S. & Leigh Brown, A.J. (2001) Genetic drift and within-host metapopulation dynamics of HIV-1 infection. Proc. Natl. Acad. Sci. USA 98:6975-6980.
  18. Frost, S.D.W., Martinez-Picado, J., Ruiz, L., Clotet, B., & Leigh Brown, A.J. (2002) Viral dynamics during structured therapy interruptions of chronic human immunodeficiency virus type 1 infection. J. Virol. 76:968-979.
  19. Prado, J.G., Wrin, T., Beauchaine, J., Ruiz, L., Petropoulos, C.J., Frost, S.D.W., Clotet, B., D.Aquila, R.T., & Martinez-Picado, J. (2002) Amprenavir resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity. AIDS 16:1009-1017.
  20. Martinez-Picado, J., Morales-Lopetego, K., Wrin, T., Prado, J.G., Frost, S.D.W., Petropoulos, C.J., Clotet, B., & Ruiz, L. (2002) Selection of drug-resistant HIV-1 mutants in response to repeated structured treatment interruptions. AIDS 16:895-899.
  21. Quigg, M., Frost, S.D.W., McDonagh, S., Burns, S.M., Clutterbuck, D., McMillan, A., Leen, C.S., & Leigh Brown, A.J. (2002) Association of antiretroviral resistance genotypes with response to therapy – comparison of three models. Antiviral Therapy (in press).
  22. Frost, S.D.W. (2002) Dynamics and evolution of HIV-1 during structured therapy interruptions. AIDS Reviews (in press).
  23. Martinez-Picado, J., Frost, S.D.W., Izquierdo, N., Morales-Lopetegi, K., Marfil, S., Puig, T., Cabrera, C., Clotet, B., & Ruiz, L. (2002) Viral evolution during structured treatment interruptions in chronically HIV-infected individuals. J. Virol. (in press).
  24. Leigh Brown, A.J., Frost, S.D.W., Mathews, W.C., Dawson, K., Hellman, N.S., Daar, E.S., Richman, D.D., & Little, S.J. (2003) Transmission fitness of drug resistant HIV and the prevalence of resistance in the antiretroviral-treated population. J. Infect. Dis. (in press).

Links

Links to come...

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Copyright © Simon Frost, 2002.