Dear Sergei,

Recently, I submitted a paper about evolution. I used REL to investigate the positive selection.

One reviewer asked me "Were models implementing variable dS ratios also run? Were there any difference in terms of results?"

So I have a question: How to run the models implementing variables dS ratios?

I would like to introduce how I use Datamonkey, maybe I miss something:
When I run Datamonkey, I usually execute an automatic model selection tool to find the best modle first, then according to the selestion results, I set the nucleotide substitution bias model (AC, CT, CG...something like that), then run the analysis, finally get the results.
Is this process right?

Thank you very much!
Best regards,

Sundy

Dear Sergei,

Thank you very much!
I got it.
Best,

Sundy